Are proteases the key to managing a soyabean diet in monogastrics? Complete digestion of protein is a key to animal health, weight gain and profitability. A strong protease blend can make all the difference.
The Problem with Protein
Protein is difficult for monogastrics to digest for numerous reasons. Undigested protein can wreak havoc on the animal’s digestive system, by allowing the production of harmful metabolites that can lead to necrotic enteritis or death. The key is to stop this process before it happens.
Protein is a vital nutritional component for most of the biologically active compounds, as well as the formation of the building blocks of the body. Typically, monogastrics are only able to digest 80 to 90% of crude protein and amino acids in the foregut. The remainder makes its way to the hindgut, where it serves as food for opportunistic pathogens to proliferate, producing harmful metabolites like indoles and phenols, and causing inflammation, which in turn compromises the lining of the small intestine, leading to necrotic enteritis.
Some of the metabolites produced are lethal to animals if generated in large enough quantities. Smaller amounts can also be lethal if produced over a longer period. Affected animals must be culled, and those that recover lose a significant amount of weight in the effort to get well, potentially causing additional economic losses.
Soyabean and Trypsin Inhibitors
Trypsin inhibitors might be the most important factor leading to the failure of complete digestion of crude protein and amino acids in monogastrics.
Soyabean, the most commonly used protein source in feed for monogastrics, has the advantage of higher digestibility and a good balance of amino acids. However, it is rich in variety of anti-nutritional factors, such as soyabean trypsin inhibitors, particularly the Kunitz trypsin inhibitor and Bowman-Birk trypsin inhibitor.
DigeGrain Pro 6 – The Solution
DigeGrain Pro 6 is a revolutionary solution to these challenges. It is a broad-spectrum blend of proteases, which can break down a variety of animal and plant-based proteins. It is stable through a wide pH range, pellet and heat-stable, resistant to gastric juices, and works effectively at the normal body temperature of monogastrics.
Deactivating trypsin inhibitors, DigeGrain Pro 6 works efficiently to improve the digestibility of amino acids in the presence or absence of proteins.
DigeGrain Pro 6 works synergistically with endogenous enzymes such as trypsin and chymotrypsin, which are also serine proteases. It behaves like an allosteric enzyme (having an additional binding site for effector molecules), which is helpful in the control of cellular metabolism.
Due to its synergistic nature, DigeGrain Pro 6 can be used with many other enzymes such as phytase, xylanase or other NSPases. It also digests the kafirin protein (which protects starch granules) present in some feed ingredients, such as sorghum.
A serine protease, DigeGrain Pro 6 has endo-proteolytic catalytic activity dependent on a triad of aspartate, histidine and serine residues. It cleaves polypeptide chains at positively charged arginine and lysine residues or large hydrophobic phenylalanine, tryptophan and tyrosine residues.
DigeGrain Pro 6 also helps to increase the serum level of systemic enzymes, which activate α-2-macroglobulin. A serum protein, α-2-macroglobulin facilitates the binding and removal of foreign peptides, excessive inflammatory mediators and auto-toxic endogenous proteins, thereby supporting balanced humoral and cell-mediated immune function and helping to relieve systemic inflammation.
DigeGrain Pro 6 helps to reduce the impact of disease stress and its secondary complications by targeting the circulating immune complexes from the blood, degrading the toxins and facilitating their removal from the system via phagocytes.